Publication - Article

Synthesis and bioactivity of nobilamide B

RSC Advances, 4(71), 37609-37612, 2014


  • M P V Jacinto - University of the Philippines System
  • M S Flores - University of the Philippines System
  • Z Lin - University of Utah


An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.